By Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore Mazzone MD (eds.)
This ebook offers a accomplished survey of adipose tissue, its physiological capabilities, and its function in ailment. the amount spans the whole diversity of adipose tissue experiences, from simple anatomical and physiological study to epidemiology and scientific reports. The authors are exclusive researchers, clinicians and epidemiologists. they've got integrated groundbreaking contemporary reviews into conventional versions of adipose tissue houses.
Chapters on famous homes of adipokines leptin and adiponectin are complemented through an advent to a singular view of adipose tissue as a dynamic organ that regulates systemic substrate availability and metabolism, besides a number of different discrete features. This novel notion is extended.
Worldwide tendencies in weight problems are mentioned from an evolutionary viewpoint and factors of the present weight problems epidemic are postulated. also, researchers and clinicians learn the organization and strength position of adipose tissue in sickness mediation and provide epidemiological facts. This quantity concludes with a considerate and cutting edge dialogue of varied techniques to inducing and maintaining weightloss in overweight
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AP2 is probably involved, as it forms a complex with hormone-sensitive lipase (HSL) and aP2 –/– mice have a decreased release of fatty acids from adipose tissue (77). The efflux of fatty acids probably involves both diffusion and transport by specific plasma membrane proteins as their uptake. Lipolysis is controlled mainly by the enzyme HSL, whose activity is regulated principally by catecholamines and insulin through the cAMP–PKA pathway. However, it is now clear that HSL is also controlled by other mechanisms and that other lipases are involved in adipocyte TAG hydrolysis.
Adipose Tissue and Adipokines in Health and Disease by Saverio Cinti MD (auth.), Giamila Fantuzzi PhD, Theodore Mazzone MD (eds.)