By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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Extra info for Advances in Cancer Research, Vol. 15
1964). Live virus is essential in inducing immunity against the tumor cells. Habel (1962) postulated that virus, upon inoculation into adult hamsters, transforms certain cells in the animals which then develop TSTA identical to those present on tumor cells subsequently used for challenge. The virus thus codes for the synthesis of new antigens unrelated to capsid antigen which sensitize the host against challenge of SV40 tumor cells. 24 J . S. BUTEL, S. S. TEVETHIA, AND J . L. , 1963). , 1967), and ( b ) cell membranes isolated from SV40 tumor cells induced a state of immunological tolerance to SV40 TSTA in newborn hamsters (Tevethia and Rapp, 1966).
Once integrated, the viral mRNA is masked by attached regions of cell rnRNA so that interferon no longer recognizes i t as being viral in origin. C. TRANSCRIPTION OF THE VIRALGENOME IN TRANSFORMED CELLS The viral DNA shown by the above experiments to be present in SV40-transformed cells was obviously being transcribed to some degree. This was evident in that virus-specific antigens were associated with such transformed cells (Section IV). It was important to determine the degree to which transcription did occur.
After centrifugation to equilibrium in cesium chloride PAPOVAVIRUS SV40 37 in the presence of ethidium bromide, the hybridizable material was found in the cellular DNA band in the gradient. ( d ) It is not present in the form of free molecules the size of a single SV40 genome. The Hirt (1967) salt precipitation method, which separates large and small molecules of DNA, showed that the hybridizable regions were found in the precipitate of cellular DNA. ( e ) The viral and cellular DNA’s are not separated by alkaline denaturation and centrifugation in a sucrose gradient.
Advances in Cancer Research, Vol. 15 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)