By Rhonda Yantiss
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a quantity within the Advances in Surgical Pathology sequence, positive factors chapters on present and imminent alterations within the box with an emphasis on sensible matters, fresh advancements, and rising concepts.
Created as a short assessment for use in the course of pathologic evaluate of melanoma specimens from the decrease gastrointestinal tract, this booklet comprises the newest information about rising endoscopic thoughts that relief in tumor category and staging, mechanisms of pathogenesis, and medical management.
It combines gross and microscopic photographs and uncomplicated tables for speedy reference with a succinct, accomplished evaluation of matters vital to administration of sufferers with colorectal carcinoma. not just does it talk about the utilized drawback of melanoma epidemiology and prevention, the ebook additionally covers pathological positive aspects of melanoma precursors. Plus, an creation to destiny diagnostic and remedy modalities, resembling biomarker research, chemotherapeutic recommendations, designated molecular cures, and competitive multidisciplinary methods to sufferers with complex level disease.
- Emphasizes clinically and practically relevant information, including pathology reports and molecular test results
- Covers suitable surgical anatomy, gross exam, and specimen guidance suggestions to assist within the dealing with of surgical resection specimens
- Provides a uncomplicated wisdom of surgical pathology and molecular review of colonic and appendiceal cancer
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Additional info for Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix
30. Hiraoka S, Kato J, Fujiki S, et al. The presence of large serrated polyps increases risk for colorectal cancer. Gastroenterology [Comparative Study Multicenter Study] 2010;139(5):1503–1510, 1510 e1–3. 31. Li D, Jin C, McCulloch C, et al. Association of large serrated polyps with synchronous advanced colorectal neoplasia. Am J Gastroenterol 2009;104(3):695–702. 32. Schreiner MA, Weiss DG, Lieberman DA. Proximal and large hyperplastic and nondysplastic serrated polyps detected by colonoscopy are associated with neoplasia.
All Rights Reserved. 24 Section I • Introduction HEREDITARY POLYPOSIS SYNDROMES Lynch Syndrome Lynch syndrome (hereditary nonpolyposis colorectal cancer) is the most common colon cancer susceptibility syndrome. As discussed in Chapter 11, it is an autosomal dominant disorder caused by a germline mutation in one of several DNA mismatch repair genes, including MSH2, MLH1, MSH6, PMS1, and PMS2. Patients may have heritable cancers limited to the colorectum or, more classically, an increased risk for a variety of malignancies, including endometrial, ovarian, urologic, gastric, small bowel, pancreatic, and central nervous system tumors.
Curr Gastroenterol Rep [Review] 2008;10(5):490–498. 27. Noffsinger AE, Hart J. Serrated adenoma: a distinct form of non-polypoid colorectal neoplasia?. Gastrointest Endosc Clin N Am [Review] 2010;20(3):543–563. 28. Kahi CJ, Hewett DG, Norton DL, et al. Prevalence and variable detection of proximal colon serrated polyps during screening colonoscopy. Clin Gastroenterol Hepatol [Evaluation Studies] 2011;9(1):42–46. 29. Parra-Blanco A, Nicolas-Perez D, Gimeno-Garcia A, et al. The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized study.
Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix by Rhonda Yantiss